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Center for Clinical and Community Research
Vision Statement
The Center for Clinical and Community Research enhances patient-oriented translational research in pediatrics that leads to advancements in health care promotion and improves the prevention, diagnosis, and treatment of childhood diseases in hospitals, outpatient settings and our communities. The Center identifies the optimal methods for delivering preventive services and other health care to children and their families, paying special attention to disadvantaged and minority populations. Collaborative investigations with health policy experts, medical geographers, and health services researchers contribute to the overall research program.
Major Strategic Goals
- Increase the amount of National Institutes of Health (NIH) and foundation support for clinical and community pediatric health research.
- Increase research productivity.
- Enhance scientific development within CRI by expanding the number of independent investigators in clinical, health services, and community research.
- Build and strengthen collaborations between multiple partners, both within the institution and at other academic institutions, especially members of the Washington Regional Institute for Clinical and Translational Science (WRICTS).
- Expand the infrastructure of the General Clinical Research Center (GCRC) and the Pediatric Pharmacology Research Unit (PPRU).
The Center for Clinical and Community Research has three major NIH-funded infrastructural components:
General Clinical Research Center (GCRC)
Bio Statisitcs and Informatics (BSI)
- Robert Mc Carter, MD, program director
The Pediatric Pharmacology Research Unit (PPRU)
These components were developed and funded to provide infrastructure for the efficient and responsible conduct of clinical and pharmacological research protocols and for the education of medical trainees, nurses, and other healthcare professionals in patient-oriented research.
The GCRC supports almost all investigator-initiated, peer-reviewed, patient-oriented, research. It features a joint outpatient/inpatient research unit with a full nursing staff, coordinated by nurse manager Marlene Lee, RN. The GCRC also supports clinical research protocols in Children’s National Medical Center’s inpatient units and emergency department, as well as in the community. Five core services--Genetics, Neuropsychological Evaluation, Bionutrition, Biostatistics, and Informatics and Bioanalytics--assist investigators to conduct efficient and high-quality clinical investigations.
The Biostatistics and Informatcs provides state-of-the-art support to investigators in the planning, implementation, and analysis of studies requiring quantitative methodologies and data management. Services include consultation on appropriate study design and data acquisition and analysis, evaluation of the comparative feasibility and validity of alternative study designs, calculation of sample size for statistical precision, and training on study design and biostatistics.
The PPRU supports investigators in the design and conduct of pharmacological studies of both new and off-patent drugs in neonates, infants and children. These investigations aim to improve the labeling of drugs for use in pediatric patients. The PPRU enables the research necessary to elucidate the impact of pharmacogenetics/pharmacogenomics and growth and development on drug disposition and action in neonates, infants, children, and adolescents. Incorporating this new knowledge in pediatric pharmacotherapy and in the design of new studies certainly will lead to more safe and efficacious drugs for all children. As part of a National PPRU Network, the PPRU at Children’s further facilitates collaboration with other academic institutions, the Food and Drug Administration (FDA), NIH, and the pharmaceutical industry.
For more information contact:
Center Administrators
Dawn Griffiths
Center for Clinical and Community Research
dgriffit@cnmc.org
Elise Ward
Center for Biostatistics and Informatics
eward@cnmc.org
Center Directors
- Jill G. Joseph, MD, PhD
Director, Center for Clinical and Community Research
jjoseph@cnmc.org
- Mendel Tuchman, MD
Director, General Clinical Research Center (GCRC)
steach@cnmc.org
- Robert Mc Carter, MD
Director, Center for Biostatistics and Informatics (BSI)
rmccarter@cnmc.org
- John N. Van Den Anker, MD, PhD
Director, Pediatric Pharmacology Research Unit (PPRU)
jvandena@cnmc.org
Children's Research Institute
Children's National Medical Center
111 Michigan Avenue, NW
Washington, DC 20010
Phone - (202) 476-3109
Fax - (202) 476-6014
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